During later stages, you might develop jaundice, which is yellowing of the eyes or skin; gastrointestinal bleeding; abdominal swelling from fluid building up in the belly; and confusion or drowsiness. One study found 34% increased risk of cardiovascular mortality among NAFLD patients compared to the general Minnesota population over a 7.6year follow-up [6]. Cirrhosis of the Liver: What is It, Symptoms, Causes & Stages Some include inflammation and scarring of the bile ducts, known as primary sclerosing cholangitis; iron buildup in the body - what we call hemochromatosis; copper accumulation in the liver, which is a rare condition called Wilson's disease; and inflammation from the body's own immune system harming liver cells, known as autoimmune hepatitis. Flowchart of the patients. The probability of being alive three years after decompensation is only 30%. Treating the cause of the cirrhosis is also crucial. CAS A total of 10/151 (7%) patients developed cirrhosis in the NAFLD group and 19/94 (20%) in AFLD group (p=0.03). Information was obtained from National Centre of Addiction Medicine in Iceland on whether or not the patients had undergone addiction therapy before or after the time of the index liver biopsy. Nonalcoholic steatohepatitis (NASH) is a form of nonalcoholic fatty liver disease in which there is inflammation and destruction of liver cells. Sign up for free, and receive liver transplant and decompensated cirrhosis content, plus expertise on liver health. Yellow discoloration in the skin and eyes, called jaundice. Exp Mol Pathol. 1C: Portal/periportal. All medical records from these patients were examined with respect to the following exclusion criteria: 1) presence of acute or chronic liver disease: PBC, autoimmune hepatitis, alfa-1-antitrypsin deficiency, hemochromatosis and viral hepatitis. The mean liver-related death rate among the general population during the study period was 0.1% of all deaths. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers. Semin Liver Dis. Medical Clinics of North America. 3: Bridging fibrosis. In the NAFLD group, two died of breast cancer and one each of prostate cancer, multiple myeloma, endometrial cancer and one of small cell lung cancer. Based on this we were able to show an association in the total study cohort between the stage of fibrosis and the prognosis. Few studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). Article other information we have about you. If you have cirrhosis, you may be eligible for Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI) benefits. 1999, 116: 1413-1419. Among patients diagnosed with cirrhosis a somewhat higher proportion developed ascites in the AFLD group, 11/19 (58%) vs. NAFLD, 3/10 (30%) (p=0.004).